Protect your health with
BerbaPrime

High-strength berberine supplement HCL 97% (1500mg) offers a natural way to support your health every day
  • CheckmarkSupports a healthy metabolism*
  • CheckmarkSupports healthy cholesterol levels*
  • CheckmarkSupports healthy blood sugar levels*
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Powerful, protective health benefits straight from nature

Used in traditional Chinese medicine for thousands of years, hundreds of studies have now revealed the extraordinary health benefits of berberine

This entirely natural, plant-based alkaloid is so powerful that scientists believe it could help protect. against - and even help treat- chronic health conditions like high cholesterol, metabolic syndrome, diabetes and heart disease - the leading cause of death worldwide.

Supports healthy blood sugar levels

Berberine can help control blood sugar by activating an enzyme called AMPK (AMPK-activated protein kinase)

AMPK increases the movement of glucose (sugar) from your blood into your cells, increases the breakdown of that glucose into energy (a process called glycolysis) and slows production of glucose in the liver.

By controlling how your body processes glucose and improving insulin resistance, berberine can help support healthy blood sugar levels.

In fact, studies have shown that berberine can significantly lower blood sugar levels in people with type 2 diabetes' and may even be as effective as some diabetes medications

1

In a 12 week study of 116 people with type 2 diabetes, 1 gram of berberine per day lowered fasting blood sugar by 20% and average long-term blood sugar levels by 12%[3]

2

In another study of 80 people with type 2 diabetes, 480mg of berberine per day for 12 weeks lowered blood sugar levels just as effectively as the blood sugar control drug metformin[4]

3

A 2021 review of published clinical research concluded that berberine can improve type 2 diabetes by improving insulin resistance[5]

4

An analysis of 28 different studies revealed that berberine was better at lowering blood pressure than a placebo, and that a combination of berberine and blood sugar control drugs was more effective than drugs alone[6]

5

Research has found that due to its similar effects to the prescription drug metformin, berberine could be a potential treatment for type 2 diabetes[7]

Supports healthy cholesterol levels

High levels of LDL, or "bad" cholesterol and triglycerides increase your risk of heart disease and stroke. But studies have shown that berberine can lower cholesterol and triglycerides.

Berberine supplements reduces PCSK9 levels. PCSK9 is an enzyme that prevents your body from. removing LDL cholesterol efficiently. It does this by destroying a protein called LDL receptors. LDL receptors help carry LDL cholesterol to your liver where it is broken down and got rid of.

By reducing PCSK9 and enabling more LDL cholesterol to be moved to and. broken down in your liver, berberine helps your body lower LDL cholesterol. more efficiently [8, 9]

Studies have also found that berberine can also reduce levels of an enzyme called apolipoprotein B by as much as 15% in just 4 weeks [10, 11]. High ApoB levels can also increase your risk of developing heart disease. By reducing both ApoB and PCSK9, berberine can help protect your heart health

1

A 2013 study found that 500mg of berberine twice a day reduced total cholesterol, LDL “bad” cholesterol and triglycerides, and increased HDL “good” cholesterol within 3 months[12]

2

The same study found that when people stopped taking berberine, their LDL cholesterol and triglyceride levels increased, but improved when they started taking berberine again

3

People with diabetes and high cholesterol taking 1 gram of berberine per day showed lower total cholesterol, LDL cholesterol and triglyceride levels after 3 months[3]

4

A meta-analysis of 27 different studies found that berberine combined with cholesterol-lowering medications reduced total and LDL cholesterol more effectively than when the medications were taken alone[13]

Supports a healthy metabolism

Berberine activates the AMPK enzyme, which has been called "the guardian" of the metabolism[14, 15].

AMPK plays a crucial role in regulating the metabolism of fats and carbohydrates. It restricts activity within your cells that use energy, like fatty acid synthesis (the creation of fatty acids).And it helps cell activity that produces energy, like glycolysis and glycogenolysis - the conversion of glycogen and glucose into

By activating AMPK, which helps control how your body breaks down and uses energy, berberine can help support a healthy metabolism..

Premium, authentic berberine derived from berberis aristata

Safe, effective, non-prescription formula
Manufactured in an ISO9001 and GMP certified facility

Lab tested for purity and quality Gluten-free, lactose-free & vegan friendly

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Daily health support with clinically proven plant power.

Many clinical studies have proven the beneficial effects of berberine on blood sugar, cholesterol and. metabolism. Click here to see just some of them

Research also shows that berberine can support your everyday health in several other important ways:

  • Reduces high blood pressure

    Berberine may help lower blood pressure when paired with lifestyle changes, and has been found to lower blood pressure more effectively when paired with medication than with medication alone[13]

  • Promotes weight loss

    Berberine may help reduce body fat due to its effects on metabolism, by activating brown adipose tissue[17], a healthy type of fat which burns calories, and by inhibiting the growth of fat cells[18]

  • Promotes gut health

    Berberine may help improve intestinal health by removing harmful bacteria and encouraging good bacteria to grow[19]

  • Has antioxidant and anti-inflammatory effects

    Berberine may treat diabetes and other inflammatory health issues by reducing inflammation and oxidative stress

  • Improves PCOS symptoms

    Berberine may treat diabetes and other inflammatory health issues by reducing Berberine may improve some of the symptoms of polycystic ovarian syndrome due to its comparable effects to the drug metformin[21,22,23] and oxidative stress[20]

  • Promotes heart health

    Berberine may help reduce your risk of developing heart disease due to its positive effects on cardiovascular risk factors such as high cholesterol, high blood pressure and insulin resistance

Reducing your cholesterol levels, controlling your blood sugar and blood pressure and maintaining a healthy weight could help reduce your risk of developing serious health issues like diabetes, heart disease and stroke.

By promoting healthy cholesterol levels, blood sugar balance, weight loss and more, BerbaPrime can help you lead a healthier, more balanced life. [16,24]

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Purity and quality guaranteed.

BerbaPrime is manufactured in the USA in an ISO9001 and GMP certified facility.

Our premium, authentic berberine undergoes strict quality control processes to ensure it is pure, safe and effective. We follow HACCP guidelines along with rigid internal safety and cGMP protocols to protect the integrity of the product from start to finish.

Which means you can purchase BerbaPrime with confidence, knowing you are protected by the highest standards of quality and safety.

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BerbaPrime - Berberine Supplement

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FAQ

You'll find the answers to our most frequently asked questions below. If your question hasn't been covered or if you'd like further information about BerbaPrime or any of the topics covered below, please feel free to get in touch. Our Customer Care team will be delighted to talk to you about BerbaPrime. Click here to contact us.

BerbaPrime is available to purchase from the website HealthNutrition.com and is also available on Amazon.com and other select suppliers.

Currently BerbaPrime is not available at GNC or other local retailers. We recommend purchasing directly at HealthNutrition.com to avoid fake or counterfeit products.
Yes. Berberine has been extensively researched and many clinical studies have verified its ability to help support healthy blood sugar levels, cholesterol levels and more.

Click here to see just some of the published clinical studies.
Many of the studies conducted on berberine show effective results within a period of 90 days. Results will differ between individuals, but you should expect to see results over the course of 3 months.

For optimal results we recommend that you take berberine for at least 3 months in conjunction with a suitable healthy diet and lifestyle.

Don't forget, when you order anything over a one month supply of BerbaPrime you are fully covered by our 100-day money back guarantee. Please click here to see our refund policy.
BerbaPrime is recommended for anyone who wants to:

  • Regulate their blood sugar levels
  • Reduce their cholesterol levels
  • Regulate their metabolism
  • Reduce their risk of heart disease
  • And more
Lowering your cholesterol levels and maintaining a healthy blood sugar balance could help reduce your risk of developing serious health issues like diabetes, heart disease and stroke.

BerbaPrime is an easy, natural and affordable way to help protect your daily health.

Please note the following cautions:

  • Berberine should NOT be taken by pregnant or nursing mothers and children under the age of 18.
  • Individuals with a known medical condition should consult a doctor before using this or any other dietary supplement.
  • Berberine can interact with a number of other medications including medications for: blood pressure, cholesterol, seizures, organ transplant, autoimmune disease and mental health disorders.
Take 1 capsule 3 times per day, preferably a few minutes before or with food.

To get the full benefits of BerbaPrime and to help keep blood sugar levels stable, spread the daily dosage evenly throughout the day.

Take with food to help reduce the blood sugar and lipid spikes that occur immediately after eating.

Do not exceed the recommended dose.
Berberine has been shown to be generally well-tolerated in studies. However, some people may experience gastrointestinal side effects from berberine, including:

  • Stomach upset
  • Cramping
  • Diarrhea
If you experience any of these side effects, reducing the dosage for a time may help. We recommend reducing to 1 capsule per day before slowly progressing to 3 times per day.

Taking too much berberine at once can also cause gastrointestinal side effects, so it is important to take BerbaPrime only as directed and not to exceed the recommended dose.

Please note the following cautions:

  • Berberine should NOT be taken by pregnant or nursing mothers and children under the age of 18.
  • Individuals with a known medical condition should consult a doctor before using this or any other dietary supplement.
  • Berberine can interact with a number of other medications, including medications for: blood pressure, cholesterol, seizures, organ transplant, autoimmune disease and mental health disorders.
  • Berberine can lower blood pressure. Taking berberine when you already have low blood pressure, especially if you are already taking medications that reduce blood pressure can risk pushing your levels too low.
  • Berberine should not replace any medical treatment.
Always consult your doctor before using this or any other dietary supplement.
Although clinical trials have shown that berberine combined with metformin or other oral diabetes drugs lowered blood sugar more effectively than the drugs alone, if you are taking a diabetes medication – or any other medication – you should consult your doctor before using BerbaPrime or any other dietary supplement.

BerbaPrime should not replace any medical treatment. Always consult a doctor before using this or any other dietary supplement.
Each BerbaPrime capsule contains 500mg of authentic, 97% pure berberine HCL derived from berberis aristata.

BerbaPrime also contains: microcrystalline cellulose, magnesium stearate and silica. These commonly used additives in supplements enhance the stability and improve the bioavailability of the active ingredients, which ensures consistent production of a high-quality product and makes it easier for your body to use the supplement comfortably and safely.

The capsules are made from hypromellose, which are suitable for both vegetarians and vegans.
Each capsule contains 500mg of berberine HCL 97%, giving you 1500mg of berberine per daily serving.
BerbaPrime uses berberine hydrochloride derived from the root bark of the berberis aristata plant.
Our premium berberine aristata is reputably sourced from China, one of the native ranges of this species where it has a long history of traditional medicinal use.

Our berberine is thoroughly tested and verified as authentic and of the highest quality, and it undergoes strict quality control processes to ensure it is pure, safe and effective to use in BerbaPrime.
We take quality and safety extremely seriously and BerbaPrime is produced and controlled to international quality standards throughout every step of the manufacturing process.

BerbaPrime is manufactured in the USA in an ISO9001 and Good Manufacturing Process (GMP) certified facility using authentic, reputably sourced Chinese berberine.

Our berberine is thoroughly tested and verified as authentic and of the highest quality, and it undergoes strict quality control processes to ensure it is pure, safe and effective to use in BerbaPrime.

Throughout the entire manufacturing process we follow HACCP guidelines along with rigid internal safety and cGMP protocols to protect the integrity of the product from start to finish.

We also use transparent capsules, enabling you to see and verify the color of the berberine inside. BerbaPrime is yellow in color, although the berberine plant can vary on the color spectrum from orange to yellow hues.

All this means you can be sure that when you purchase BerbaPrime, you are getting a safe, genuine, effective supplement of the highest quality.
Yes. We offer an industry-leading 100-day money-back guarantee when you order anything over a one month supply of BerbaPrime.

If, after using BerbaPrime as directed for at least 50 days, you don't believe it is supporting your health as promised, simply email us within 50-100 days of receiving your order and we will happily refund your money, excluding a $15 fixed fee to cover shipping and admin costs.

Terms and conditions apply. Please click here to see the full terms of our refund policy.
We can ship BerbaPrime to US, Canada and the UK.
Delivery times depend on your location. We ship orders from the closest warehouse to you in the USA or UK.

After receiving your order, we will dispatch it within 24-48 hours. Once dispatched, here's when you can expect to receive your order:

  • USA: 3-7 working days
  • UK: 5-10 working days
  • Canada: 5-10 working days
Please note: We do not dispatch on US or UK public holidays. There may also be a backlog of orders after a public holiday, potentially causing an extra 1-2 days delay with deliveries.
Each BerbaPrime capsule contains 500mg of authentic, 97% pure berberine HCL derived from berberis aristata.

Clinical References

  • Guo J, Chen H, Zhang X, Lou W, Zhang P, Qiu Y, Zhang C, Wang Y, Liu WJ. The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Oxid Med Cell Longev. 2021 Dec 15;2021:2074610. doi: 10.1155/2021/2074610. PMID: 34956436; PMCID: PMC8696197.
  • Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med. 2012;2012:591654. doi: 10.1155/2012/591654. Epub 2012 Oct 15. PMID: 23118793; PMCID: PMC3478874.
  • Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning G. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008 Jul;93(7):2559-65. doi: 10.1210/jc.2007-2404. Epub 2008 Apr 8. PMID: 18397984.
  • Sanjari M, Shamsinejad B, Khazaeli P, Safi Z, Mirrashidi F, Naghibzadeh-Tahami A. Safety and efficacy of Berberis integerrima root extract in patients with type 2 diabetes. A parallel intervention based triple blind clinical trial. J Diabetes Metab Disord. 2020 Mar 4;19(1):71-80. doi: 10.1007/s40200-019-00478-z. PMID: 32550158; PMCID: PMC7270296.
  • Ye Y, Liu X, Wu N, Han Y, Wang J, Yu Y, Chen Q. Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Front Pharmacol. 2021 Apr 26;12:653887. doi: 10.3389/fphar.2021.653887. PMID: 33981233; PMCID: PMC8107691.
  • Liang Y, Xu X, Yin M, Zhang Y, Huang L, Chen R, Ni J. Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis. Endocr J. 2019 Jan 28;66(1):51-63. doi: 10.1507/endocrj.EJ18-0109. Epub 2018 Nov 3. PMID: 30393248.
  • Wang H, Zhu C, Ying Y, Luo L, Huang D, Luo Z. Metformin and berberine, two versatile drugs in treatment of common metabolic diseases. Oncotarget. 2017 Sep 11;9(11):10135-10146. doi: 10.18632/oncotarget.20807. PMID: 29515798; PMCID: PMC5839379.
  • Cameron J, Ranheim T, Kulseth MA, Leren TP, Berge KE. Berberine decreases PCSK9 expression in HepG2 cells. Atherosclerosis. 2008 Dec;201(2):266-73. doi: 10.1016/j.atherosclerosis.2008.02.004. Epub 2008 Feb 15. PMID: 18355829.
  • Ataei S, Kesharwani P, Sahebkar A. Berberine: Ins and outs of a nature-made PCSK9 inhibitor. EXCLI J. 2022 Aug 17;21:1099-1110. doi: 10.17179/excli2022-5234. PMID: 36381647; PMCID: PMC9650693.
  • Cicero AF, Rovati LC, Setnikar I. Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigation. Arzneimittelforschung. 2007;57(1):26-30. doi: 10.1055/s-0031-1296582. PMID: 17341006.
  • Shidfar F, Ebrahimi SS, Hosseini S, Heydari I, Shidfar S, Hajhassani G. The Effects of Berberis vulgaris Fruit Extract on Serum Lipoproteins, apoB, apoA-I, Homocysteine, Glycemic Control and Total Antioxidant Capacity in Type 2 Diabetic Patients. Iran J Pharm Res. 2012 Spring;11(2):643-52. PMID: 24250489; PMCID: PMC3832145.
  • Derosa G, D'Angelo A, Bonaventura A, Bianchi L, Romano D, Maffioli P. Effects of berberine on lipid profile in subjects with low cardiovascular risk. Expert Opin Biol Ther. 2013 Apr;13(4):475-82. doi: 10.1517/14712598.2013.776037. Epub 2013 Feb 27. PMID: 23441841.
  • Lan J, Zhao Y, Dong F, Yan Z, Zheng W, Fan J, Sun G. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015 Feb 23;161:69-81. doi: 10.1016/j.jep.2014.09.049. Epub 2014 Dec 10. PMID: 25498346.
  • Jin Y, Liu S, Ma Q, Xiao D, Chen L. Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes. Eur J Pharmacol. 2017 Jan 5;794:106-114. doi: 10.1016/j.ejphar.2016.11.037. Epub 2016 Nov 22. PMID: 27887947.
  • Herzig, S., Shaw, R. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol 19, 121–135 (2018). https://doi.org/10.1038/nrm.2017.95
  • Zamani M, Zarei M, Nikbaf-Shandiz M, Hosseini S, Shiraseb F, Asbaghi O. The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis. Front Nutr. 2022 Oct 14;9:1013055. doi: 10.3389/fnut.2022.1013055. PMID: 36313096; PMCID: PMC9614282.
  • Hu X, Zhang Y, Xue Y, Zhang Z, Wang J. Berberine is a potential therapeutic agent for metabolic syndrome via brown adipose tissue activation and metabolism regulation. Am J Transl Res. 2018 Nov 15;10(11):3322-3329. PMID: 30662589; PMCID: PMC6291723.
  • Habtemariam S. Berberine pharmacology and the gut microbiota: A hidden therapeutic link. Pharmacol Res. 2020 May;155:104722. doi: 10.1016/j.phrs.2020.104722. Epub 2020 Feb 24. PMID: 32105754.
  • Li Z, Geng YN, Jiang JD, Kong WJ. Antioxidant and anti-inflammatory activities of berberine in the treatment of diabetes mellitus. Evid Based Complement Alternat Med. 2014;2014:289264. doi: 10.1155/2014/289264. Epub 2014 Feb 11. PMID: 24669227; PMCID: PMC3942282.
  • Rondanelli M, Infantino V, Riva A, Petrangolini G, Faliva MA, Peroni G, Naso M, Nichetti M, Spadaccini D, Gasparri C, Perna S. Polycystic ovary syndrome management: a review of the possible amazing role of berberine. Arch Gynecol Obstet. 2020 Jan;301(1):53-60. doi: 10.1007/s00404-020-05450-4. Epub 2020 Feb 14. PMID: 32060683; PMCID: PMC7028834.
  • Zhang SW, Zhou J, Gober HJ, Leung WT, Wang L. Effect and mechanism of berberine against polycystic ovary syndrome. Biomed Pharmacother. 2021 Jun;138:111468. doi: 10.1016/j.biopha.2021.111468. Epub 2021 Mar 16. PMID: 33740526.
  • Wei W, Zhao H, Wang A, Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol. 2012 Jan;166(1):99-105. doi: 10.1530/EJE-11-0616. Epub 2011 Oct 21. PMID: 22019891.
  • Xu X, Yi H, Wu J, Kuang T, Zhang J, Li Q, Du H, Xu T, Jiang G, Fan G. Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. Biomed Pharmacother. 2021 Jan;133:110984. doi: 10.1016/j.biopha.2020.110984. Epub 2020 Nov 10. PMID: 33186794.