Testogen - Ingredients - HealthNutrition

Feel better, every day

with eleven all-natural, scientifically backed testosterone-boosting ingredients

Transparent formula

100%

safe, natural &

quality assured

Made with

11

highly effective,

natural ingredients

Ingredients backed by

25+

clinical studies &

research papers

BACKED BY SCIENCE

Ingredients sourced from nature and backed by science

Too many testosterone boosters on the market are based. on junk science and have no scientific evidence to support their claims. And the questionable ingredients and fillers some contain are the last thing your body needs to support healthy testosterone production.

Each of Testogen's 100% natural ingredients has been extensively. researched and is backed by solid, credible scientific data from. multiple studies published in reputable academic journals. Which means you get trusted, proven results with absolutely no risks or side. effects.

Testogen is 100%

Filler free

Chemical free

Synthetic free

GMO free

Soy free

Gluten free

Dairy free

Caffeine free

Inside every testosterone-boosting serving of Testogen is…

D-Aspartic Acid (2352mg)

42%

increase in testosterone after 12 days

33%

increase in luteinizing hormone after 12 days

15%

increase in testosterone after 6 days

D-aspartic acid (D-AA) is an amino acid that supports the production of luteinizing hormone in the pituitary gland. Luteinizing hormone stimulates the Leydig cells in luteinizing hormone levels, D-AA can significantly boost your testosterone production.

Men taking a daily D-AA supplement showed a 15% increase in testosterone levels after just 6 days and a huge 42% increase after 12 days⁴

The same study showed a 33% lift in luteinizing hormone after 12 days

3 days after they stopped taking D-AA, men in the above study still had, on average, 22% higher testosterone levels than at the beginning of the study

After taking D-AA for 28 days, overweight men with low testosterone levels had testosterone increases of over 20% and reported significantly better energy levels, libido, mood and vitality⁵

Because it plays such a vital role in testosterone production and is backed by such strong evidence supporting its powerful testosterone-boosting effects, Testogen contains more D-AA per serving than any other product on the market.

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Fenugreek Extract (40mg)

46%

increase in testosterone after 12 days

10%

increase in testosterone after 4 weeks

14%

increase in testosterone after 8 weeks

Fenugreek contains compounds called furostanolic saponins which are believed to boost testosterone production by inhibiting the enzymes that convert. testosterone into estrogen. Numerous studies have shown fenugreek to improve both testosterone levels and overall symptoms of low T, with study volunteers. experiencing significant improvements in their energy levels, strength, body fat, mood, libido and overall feelings of well-being.

In a study of 50 men, a daily fenugreek supplement increased testosterone levels by up to 46% in 90% of the men after 12 weeks, and improved their energy, mood and libido⁶

In men aged 43-75, a daily fenugreek supplement increased both free and total testosterone and improved their libido within 12 weeks⁷

A twice daily fenugreek and chinese bush clover extract increased testosterone up to 10.38% after 4 weeks and 14.28% after 8 weeks. It also improved men’s overall symptoms of low T⁸

Fenugreek also supports

Energy

Libido

Strength

Mood

Fat loss

After 12 weeks, men taking fenugreek extract reported improvements in their energy, mood, mental alertness and libido⁹.
Fit men taking a daily fenugreek extract and working out 4 times weekly experienced significantly improved upper and lower body strength and reduced body fat compared to those taking a placebo¹⁰.
Men taking a daily fenugreek extract and strength training 4 times a week in a different study experienced a boost in testosterone levels compared to those taking a placebo, as well as a 2% reduction in body fat¹¹.
Men aged 25-52 taking a daily fenugreek for 6 weeks enjoyed an increase in their sex drive. They also had more erections, had sex more often and had better orgasms^12,13.

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Vitamin D3 (50mcg)

20%

increase in testosterone over 12 months

18%

increase in testosterone over 9 months.

7%

decrease in SHBG over 9 months.

Studies have shown that men with sufficient vitamin D levels have significantly higher testosterone than those with low levels²³. Which means your testosterone levels could be affected if you’re not getting enough vitamin D. Your daily serving of Testogen will ensure you get the vitamin D you need to support healthy testosterone production.

A yearlong study with vitamin D deficient men found that doubling vitamin D intake increased free testosterone levels by 20.27% and total testosterone levels by 25.23%²⁴

In a 2018 study, increased vitamin D intake in older men enhanced free testosterone levels by 18.87% and significantly decreased SHBG²⁵, a protein that prevents testosterone from being used by the body, by 7.45%

A 2015 study with male Special Operations soldiers at Womack Army Medical Centre in Fort Bragg showed that low vitamin D levels were strongly linked to lower testosterone levels²⁶

Testogen uses vitamin D3 (cholecalciferol) which studies have found is the more effective form of vitamin D to supplement with²⁷. What’s more, vitamin D works even better when taken with magnesium, boron and vitamin K, which are all included in the Testogen formula too.

Vitamin D also supports

Energy

Libido

Sexual
Function

Mood

Studies have shown that vitamin D significantly reduces fatigue²⁸. That’s because vitamin D improves the activity of mitochondria - the ‘power stations’ of your cells²⁹ - which boosts your energy levels.
By increasing the amount of energy available to your cells³⁰, vitamin D can help your muscles work more efficiently. By simply increasing their vitamin D intake, professional soccer players performed better after 6 weeks³¹ and normal, healthy adults improved their cycling performance by 30% after just 2 weeks³².
A 2018 study conducted with 114 men found that increased vitamin D intake was significantly linked to improved erectile function³³. This may be because vitamin D stimulates nitric oxide production³⁴, which is vital to the erection process.
Studies have shown that people with anxiety and depression are more likely to be vitamin D deficient and that people with depression experienced a significant improvement in their symptoms after taking vitamin D^{35, 36}. Which suggests that vitamin D plays an important role in supporting your mood.

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Zinc (10mg)

50%

increase in testosterone after 6 months

79%

testosterone decrease caused by a low-zinc diet

33%

increase in testosterone after 8 weeks

Zinc plays such a vital role in testosterone production that even a mild deficiency can interfere with your testosterone levels¹⁴. Yet most men don’t get enough of this essential mineral in their diet. Which means you’re probably not getting enough of it either. The zinc in Testogen helps protect you against zinc deficiency, supporting healthy testosterone levels.

An eye-opening study found that testosterone levels in young men on a low zinc diet plummeted by a shocking 75% within just 20 weeks¹⁵

The same study also showed that when older men increased their zinc intake for 6 months, their testosterone levels increased by almost 50%

Athletes taking a daily ZMA (zinc, magnesium, vitamin B6) supplement for 8 weeks showed a 33% boost in free testosterone levels¹⁶

In a study of 88 men aged 40-60, those with normal testosterone levels had significantly higher zinc levels compared to the low testosterone group¹⁷

Zinc’s dramatic effect on testosterone production may be due to its role as an antioxidant. Your leydig cells, which produce testosterone, are particularly vulnerable to oxidative damage¹⁸. Damaged leydig cells cannot produce testosterone as efficiently, leading to a drop in T levels. By helping protect your cells from oxidative damage, zinc helps support healthy testosterone production¹⁹.

The Testogen formula uses Zinc citrate, because it’s been proven to be better absorbed than other sources of zinc²⁰.

Vitamin D also supports

Energy

Performance

Libido

Zinc is needed to form hemoglobin, which transports oxygen around your body, and insulin, which is crucial for blood sugar regulation. It also helps to break down and generate energy from food. The zinc in Testogen will help support your energy levels and ward off tiredness and fatigue.
Zinc is lost through sweat, so the more active you are the more likely you are to become deficient. Your daily dose of Testogen will keep your zinc levels topped up to help ensure your performance at the gym doesn’t suffer.

Research with male elite athletes has also shown that exercising to exhaustion can cause a temporary drop in testosterone levels. But zinc prevents this, leading researchers to conclude that zinc may benefit physical performance²¹.
Rats given 5mg of zinc per day demonstrated improved sexual behaviour and sexual function, suggesting that zinc may have a positive effect on libido and erections²².

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Korean Red Ginseng Extract 4:1 (40mg)

29%

increase in libido

60%

improvement in ED symptoms

33%

increase in satisfaction.

One of the world’s most popular natural medicinal herbs, Korean ginseng (also known as Panax ginseng) has been found in studies to enhance testosterone levels. But the main reason it’s in Testogen is because of its proven libido-boosting benefits.

In a study of 66 men, ginseng increased free and total testosterone, luteinizing hormone (which stimulates testosterone production), and DHT (a more powerful hormone than testosterone)³⁷

Studies on men with ED have shown ginseng to improve libido by almost 30%, erectile function by 37.67% and men’s overall satisfaction with their sex life by 33.79% after just 8 weeks^{38, 39}

Men treated with Korean red ginseng enjoyed a 60% improvement in ED symptoms, compared to only 30% with a drug specifically designed to treat ED⁴⁰

Experts believe that compounds in ginseng called ginsenosides are to thank for it’s beneficial effects on your sex life. Ginsenosides increase levels of dopamine and acetylcholine in the brain⁴¹, neurotransmitters which are linked to desire and arousal. Ginsenosides are also thought to improve nitric oxide production⁴², boosting the flow of blood to your penis and enhancing your erections.

Korean red ginseng also supports

Energy

Performance

Mood

Cognitive function

Fat Loss

Studies have shown that people taking ginseng experience more energy throughout the day^43,44. This could be because molecules in ginseng like polysaccharides and oligopeptides reduce oxidative stress and increase energy production in cells, helping you fight fatigue^45,46,47.
A paper published in The American Journal of Clinical Nutrition concluded that ginseng may enhance physical performance, especially if you are over 40 years old⁴⁸.
Studies have shown ginseng to significantly improve mental performance, math skills and memory, as well as reduce feelings of mental fatigue^49,50,51.
People taking Korean ginseng extract reported that their mood had improved and rated their quality of life much better compared to when they took a placebo⁵².
Studies have suggested that Korean red ginseng may increase fat breakdown and prevent the formation of new fat cells, which means it could help support your weight loss efforts^{53, 54}

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Boron (8mg)

28%

increase in testosterone after 1 week

39%

decrease in estradiol after 1 week

33%

decrease in SHBG after 6 hours

Boron is believed to increase testosterone metabolism⁵⁵. Which means more of the total testosterone in your body is converted into free testosterone - the type that gives you all the benefits.

Studies have shown that even a small amount of boron is enough to significantly boost testosterone levels and decrease estradiol levels. Estradiol is a type of estrogen, and too much of it can cause your testosterone levels to decline.

Boron also reduces SHBG levels in your blood. SHBG binds itself to testosterone, preventing it from being used by the body. By reducing SHBG, boron frees up more testosterone to keep you energized, strong and focused.

A 2011 study revealed that men taking 10mg of boron each morning experienced a 28% increase in free testosterone in just one week⁵⁶

The same study found that boron also reduced estradiol levels by 39% in one week

Just 6 hours after taking a single 10mg boron supplement, SHBG levels dropped by 9% in men in the above study

Boron isn’t just a powerful testosterone booster. It also significantly improves the absorption of the magnesium and vitamin D that are also in the Testogen formula⁵⁷. Which means that boron makes the magnesium and vitamin D even more effective.

Boron also supports

Cognitive function

Research has suggested that boron may play an important role in healthy brain function and cognitive performance, especially as you age. In studies with healthy older people, those taking just 3.25mg of boron a day had improved attention and memory and were better at eye-hand coordination tasks⁵⁸.

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Nettle Leaf Extract 4:1 (40mg)

67%

decrease in SHBG
binding to DHT

Stinging nettle roots contain compounds called ligans which prevent a protein called SHBG (sex hormone binding globulin) from binding itself to testosterone ^{59, 60, 61}.

Once testosterone is bound to SHBG your body cannot use it and it becomes useless. By reducing the amount of SHBG that binds with testosterone, stinging nettle allows more free testosterone to circulate around your body.

In one study, stinging nettle ligans prevented the binding of DHT^{62, 63}, an androgen hormone even more potent than testosterone, to SHBG by up to 67%

Research has also suggested that stinging nettle may help stop testosterone from being converted into estrogen⁶⁴. By reducing the amount of testosterone that is converted into estrogen, stinging nettle can help keep your testosterone levels higher for longer.

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Magnesium (200mg)

Studies have shown magnesium to increase both free and total testosterone, with men who exercise benefitting from the biggest increase. Which means the more active you are, the bigger the testosterone-boost you’ll get from magnesium.

Men receiving daily magnesium supplementation for 7 weeks experienced a significant increase in testosterone compared to those receiving a placebo⁶⁵

4 weeks of magnesium supplementation enhanced total and free testosterone levels in both active and sedentary men, with higher increases in the men who exercised⁶⁶

Researchers monitoring the magnesium levels of 399 older men found that men with higher magnesium levels also had higher testosterone levels⁶⁷

Despite the link between magnesium and testosterone production and the vital role it plays in many other physiological functions within the body, research shows that most men don’t consume enough magnesium, with older men in particular at higher risk of deficiency⁶⁸. Which is why we’ve added a generous 200mg dose to every Testogen serving, to ensure you get enough to support continued healthy testosterone production.

Magnesium also supports

Energy

Performance

Mood

Strength

Sleep

Magnesium is needed for energy production. Studies suggest that low levels may interfere with your body’s ability to efficiently use energy stores⁶⁹. The magnesium in Testogen will help keep your energy levels stable and prevent tiredness and fatigue.
Magnesium can boost your exercise performance by increasing the amount of glucose available to your muscles and the removal of lactate from muscles⁷⁰. In one study, triathlon athletes taking magnesium for 4 weeks had faster running, swimming and cycling times⁷¹.
Magnesium is involved in the production of serotonin, the “happy” hormone that stabilizes your mood, feelings of well-being, and happiness. One study found that 450mg daily was as effective at improving mood as an antidepressant drug⁷³.
During a 7 week strength training program, people taking a magnesium supplement experienced significantly bigger strength increases compared to those taking a placebo⁷².
Magnesium improves your sleep quality, which is vital for healthy testosterone production, energy, muscle growth and your overall health and wellness. A 2012 study showed that people taking a daily magnesium supplement slept significantly better than those taking a placebo⁷⁴.

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Vitamin B6 (20mg)

Studies have shown that vitamin B6 deficiency is linked to lower testosterone and increased estrogen levels⁷⁵, which strongly suggests that vitamin B6 is vital to the testosterone production process.

Vitamin B also plays a crucial role in your overall health and wellness. Your body is unable to store vitamin B, so you must receive a daily dose. It’s important to increase your intake of vitamin B6 as you get older, especially for testosterone production, which declines as you age.

Vitamin B6 also supports

Energy

Mood

B vitamins contribute to a normal, energy-yielding metabolism⁷⁶. The daily dose of vitamin B6 you’ll get with Testogen will support your energy levels and help reduce tiredness and fatigue.
B vitamins convert amino acids into mood-boosting chemicals like serotonin and noradrenaline⁷⁷. With Testogen, it won’t be long before you’re feeling more like yourself again.

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Vitamin K1 (20mcg)

Vitamin K helps your body absorb the vitamin D in the TestoGen formula more efficiently. Which means it increases the vitamin D’s testosterone-boosting effects.

Vitamin K also supports

Cognitive function

Mood

A 2019 study analysed 4,375 people aged between 45-79 and found that those with the highest vitamin K intake were significantly less likely to have symptoms of depression⁷⁸. Which means that vitamin K may play an important role in supporting your mood.
Studies have shown that people over 70 with the highest vitamin K intake have better cognitive performance and memory in tests⁷⁹, Which suggests that vitamin K could play an important role in keeping your brain functioning healthily, especially as you age⁸⁰.

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Bioperine® 95% Piperine (5mg)

30%

increase in
bioavailability

Bioperine is derived from black pepper and increases the bioavailability of Testogen’s ingredients by up to 30%⁸¹.

This means that your body is able to absorb and use up to 30% more of each of the active ingredients in Testogen than it would do without the Bioperine.

In other words, the Bioperine increases the effectiveness of Testogen, which means you get better results.

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OTHER INGREDIENTS

Hypromellose (vegetable capsule), maltodextrin, silica, magnesium stearate

To view the ingredients in the Testogen Instant Booster Drops, please click here.

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CLINICAL REFERENCES

[1, 2] D-aspartic acid supports production of luteinizing hormone:

D’Aniello A. D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role. Brain Res Rev. 2007 Feb;53(2):215-34. doi: 10.1016/j.brainresrev.2006.08.005. Epub 2006 Nov 21. PMID: 17118457.

D’Aniello A, Di Fiore MM, Fisher GH, Milone A, Seleni A, D’Aniello S, Perna AF, Ingrosso D. Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release. FASEB J. 2000 Apr;14(5):699-714. doi: 10.1096/fasebj.14.5.699. PMID: 10744627.

[3] D-aspartic acid supports production of luteinizing hormone:

D’Aniello A, Di Cosmo A, Di Cristo C, Annunziato L, Petrucelli L, Fisher G. Involvement of D-aspartic acid in the synthesis of testosterone in rat testes. Life Sci. 1996;59(2):97-104. doi: 10.1016/0024-3205(96)00266-4. PMID: 8699926.

[4] D-AA increased testosterone by 15% after 6 days and 42% after 12 days:

Topo E, Soricelli A, D’Aniello A, Ronsini S, D’Aniello G. The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reprod Biol Endocrinol. 2009;7:120. Published 2009 Oct 27. doi:10.1186/1477-7827-7-120. PMCID: 2774316.

[5] D-AA increased testosterone by over 20% and improved symptoms of low testosterone in overweight men with low testosterone levels:

Bloomer JR, Gunnels TA, Moran RG, Schriefer JM. Influence of a D-aspartic acid/sodium nitrate/vitamin D3 supplement on physiological parameters in middle-aged men: a pilot study. Open Nutraceuticals Journal, 2015, 8:43-48. Doi 10.2174/1876396001508010043

[6] Fenugreek increased testosterone levels by up to 46% and improved energy, mood and libido:

Maheshwari A, Verma N, Swaroop A, et al. Efficacy of FurosapTM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers. Int J Med Sci. 2017;14(1):58-66. Published 2017 Jan 10. doi:10.7150/ijms.17256. PMCID: 5278660

[7] Fenugreek increased free and total testosterone and improved libido after 12 weeks:

Rao A, Steels E, Inder WJ, Abraham S, Vitetta L. Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study. Aging Male. 2016 Jun;19(2):134-42. doi: 10.3109/13685538.2015.1135323. Epub 2016 Jan 20. PMID: 26791805.

[8] Fenugreek and bush clover extract increased testosterone and improved overall symptoms of low testosterone:

Park HJ, Lee KS, Lee EK, Park NC. Efficacy and Safety of a Mixed Extract of Trigonella foenum-graecum Seed and Lespedeza cuneata in the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. World J Mens Health. 2018;36(3):230-238. doi:10.5534/wjmh.170004 PMCID: 6119847

[9] Fenugreek extract improved energy, mood, mental alertness and libido:

Maheshwari A, Verma N, Swaroop A, Bagchi M, Preuss HG, Tiwari K, Bagchi D. Efficacy of FurosapTM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers. Int J Med Sci. 2017 Jan 10;14(1):58-66. doi: 10.7150/ijms.17256. PMID: 28138310; PMCID: PMC5278660.

[10] Fenugreek extract significantly improved body strength and reduced lower body fat compared to a placebo:

Poole C, Bushey B, Foster C, Campbell B, Willoughby D, Kreider R, Taylor L, Wilborn C. The effects of a commercially available botanical supplement on strength, body composition, power output, and hormonal profiles in resistance-trained males. J Int Soc Sports Nutr. 2010 Oct 27;7:34. doi: 10.1186/1550-2783-7-34. PMID: 20979623; PMCID: PMC2978122.

[11] Fenugreek increased testosterone levels and reduced body fat compared to a placebo:

Wilborn C, Taylor L, Poole C, Foster C, Willoughby D, Kreider R. Effects of a purported aromatase and 5α-reductase inhibitor on hormone profiles in college-age men. Int J Sport Nutr Exerc Metab. 2010 Dec;20(6):457-65. doi: 10.1123/ijsnem.20.6.457. PMID: 21116018.

[12, 13] Fenugreek extract improved libido and sexual function in men aged 25-52:

Steels E, Rao A, Vitetta L. Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation. Phytother Res. 2011 Sep;25(9):1294-300. doi: 10.1002/ptr.3360. Epub 2011 Feb 10. PMID: 21312304. Natural Medicine Journal Oct 2016, 8-10

[14] Zinc deficiency can interfere with testosterone production:

Netter A, Hartoma R, Nahoul K. Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm count. Arch Androl. 1981 Aug;7(1):69-73. doi: 10.3109/01485018109009378. PMID: 7271365.

[15] A low zinc diet caused a 75% decrease in testosterone levels after 20 weeks:

Prasad AS, Mantzoros CS, Beck FW, Hess JW, Brewer GJ. Zinc status and serum testosterone levels of healthy adults. Nutrition. 1996 May;12(5):344-8. doi: 10.1016/s0899-9007(96)80058-x. PMID: 8875519.

[16] A daily ZMA supplement increased free testosterone by 33% after 8 weeks:

Billa L.R & Conte V. Effects of a novel zinc-magnesium formulation on hormones and strength. Journal of Exercise Physiology online. 2000 Oct; vol 3-4 ISSN 1097-9751

[17] Men with normal testosterone levels had significantly higher zinc levels compared to those with low testosterone levels:

Chang CS, Choi JB, Kim HJ, Park SB. Correlation between serum testosterone level and concentrations of copper and zinc in hair tissue. Biol Trace Elem Res. 2011 Dec;144(1-3):264-71. doi: 10.1007/s12011-011-9085-y. Epub 2011 Jun 14. PMID: 21671089.

[18] Leydig cells are particularly vulnerable to oxidative damage:

Aitken RJ, Roman SD. Antioxidant systems and oxidative stress in the testes. Oxid Med Cell Longev. 2008 Oct-Dec;1(1):15-24. doi: 10.4161/oxim.1.1.6843. PMID: 19794904; PMCID: PMC2715191.

[19] Zinc protects cells against oxidative damage:

Marreiro DD, Cruz KJ, Morais JB, Beserra JB, Severo JS, de Oliveira AR. Zinc and Oxidative Stress: Current Mechanisms. Antioxidants (Basel). 2017 Mar 29;6(2):24. doi: 10.3390/antiox6020024. PMID: 28353636; PMCID: PMC5488004.

[20] Zinc citrate shows better absorption than other forms of zinc:

Wegmüller R, Tay F, Zeder C, Brnic M, Hurrell RF. Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide. J Nutr. 2014 Feb;144(2):132-6. doi: 10.3945/jn.113.181487. Epub 2013 Nov 20. PMID: 24259556; PMCID: PMC3901.

[21] Zinc may be beneficial to physical performance:

Kilic M, Baltaci AK, Gunay M, et al. The effect of exhaustion exercise on thyroid hormones and testosterone levels of elite athletes receiving oral zinc. Neuro Endocrinology Letters. 2006 Feb-Apr;27(1-2):247-252

[22] Zinc may have a positive effect on libido and erections:

Dissanayake D, Wijesinghe PS, Ratnasooriya WD, Wimalasena S. Effects of zinc supplementation on sexual behavior of male rats. J Hum Reprod Sci. 2009 Jul;2(2):57-61. doi: 10.4103/0974-1208.57223. PMID: 19881149; PMCID: PMC2800928.

[23] Men with sufficient vitamin D levels have significantly higher testosterone than those with low levels:

Wehr E, Pilz S, Boehm BO, März W, Obermayer-Pietsch B. Association of vitamin D status with serum androgen levels in men. Clin Endocrinol (Oxf). 2010 Aug;73(2):243-8. doi: 10.1111/j.1365-2265.2009.03777.x. Epub 2009 Dec 29. PMID: 20050857.

[24] Doubling vitamin D intake increased total testosterone levels by 25.23% and free testosterone levels by 20.27% in vitamin D deficient men:

Pilz S, Frisch S, Koertke H, Kuhn J, Dreier J, Obermayer-Pietsch B, Wehr E, Zittermann A. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res. 2011 Mar;43(3):223-5. doi: 10.1055/s-0030-1269854. Epub 2010 Dec 10. PMID: 21154195.

[25] Increased vitamin D intake in older men enhanced free testosterone levels by 18.87% and significantly decreased SHBG:

Tirabassi G, Sudano M, Salvio G, Cutini M, Muscogiuri G, Corona G, Balercia G. Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study. Int J Endocrinol. 2018 Jan 8;2018:3720813. doi: 10.1155/2018/3720813. PMID: 29531528; PMCID: PMC5817208.

[26] Low vitamin D levels in male Special Operations soldiers were strongly linked to lower testosterone levels:

Wentz, Laurel & CB, Berry-Caban & JD, Eldred & Q, Wu. (2015). Vitamin D Correlation with Testosterone Concentration in US Army Special Operations Personnel. Conference: Experimental Biology, Boston, MA

[27] Vitamin D3 (cholecalciferol) could potentially become the preferred choice for supplementation:

Tripkovic L, Lambert H, Hart K, Smith CP, Bucca G, Penson S, Chope G, Hyppönen E, Berry J, Vieth R, Lanham-New S. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012 Jun;95(6):1357-64. doi: 10.3945/ajcn.111.031070. Epub 2012 May 2. PMID: 22552031; PMCID: PMC3349454.

[28] Vitamin D3 (cholecalciferol) could potentially become the preferred choice for supplementation:

Nowak A, Boesch L, Andres E, Battegay E, Hornemann T, Schmid C, Bischoff-Ferrari HA, Suter PM, Krayenbuehl PA. Effect of vitamin D3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial. Medicine (Baltimore). 2016 Dec;95(52):e5353. doi: 10.1097/MD.0000000000005353. Erratum in: Medicine (Baltimore). 2017 Jan 20;96(3):e6038. PMID: 28033244; PMCID: PMC5207540.

[29] Vitamin D improves mitochondrial activity:

Sinha A, Hollingsworth K, Ball S, Cheetham, T. Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle. Endocrine Abstracts (2013) 31 OC1.6 | DOI: 10.1530/endoabs.31.OC1.6

[30] Vitamin D proven to boost energy from within the cells:

Public Release: 5-Apr-2013 Public Release: 06-Apr-2013

[31] Professional soccer players performed better after 6 weeks of vitamin D supplementation:

Koundourakis NE, Androulakis NE, Malliaraki N, Margioris AN. Vitamin D and exercise performance in professional soccer players. PLoS One. 2014 Jul 3;9(7):e101659. doi: 10.1371/journal.pone.0101659. PMID: 24992690; PMCID: PMC4081585.

[32] Vitamin D increased cycling performance by 30% after 2 weeks:

Vitamin D pill a day may improve exercise performance and lower risk of heart disease. Society for Endocrinology, Public Release: 1-Nov-2015

[33] Increased vitamin D intake was significantly linked to improved erectile function:

Tirabassi G, Sudano M, Salvio G, Cutini M, Muscogiuri G, Corona G, Balercia G. Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study. Int J Endocrinol. 2018 Jan 8;2018:3720813. doi: 10.1155/2018/3720813. PMID: 29531528; PMCID: PMC5817208.

[34] Vitamin D stimulates nitric oxide production:

Molinari C, Uberti F, Grossini E, Vacca G, Carda S, Invernizzi M, Cisari C. 1α,25-dihydroxycholecalciferol induces nitric oxide production in cultured endothelial cells. Cell Physiol Biochem. 2011;27(6):661-8. doi: 10.1159/000330075. Epub 2011 Jun 17. PMID: 21691084.

[35] People with anxiety and depression are more likely to be vitamin D deficient:

Armstrong, D.J., Meenagh, G.K., Bickle, I. et al. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol 26, 551–554 (2007). Doi: 10.1007/s10067-006-0348-5

[36] Vitamin D significantly improved symptoms of depression:

Jorde R, Sneve M, Figenschau Y, Svartberg J & Waterloo K. Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial. Journal of Internal Medicine. 2008 Nov. doi: 10.1111

[37] Ginseng increased free and total testosterone, LH and DHT:

Salvati G, Genovesi G, Marcellini L, Paolini P, De Nuccio I, Pepe M, Re M. Effects of Panax Ginseng C.A. Meyer saponins on male fertility. Panminerva Med. 1996 Dec;38(4):249-54. PMID: 9063034.

[38] Ginseng improves libido, erectile function and overall satisfaction:

Kim TH, Jeon SH, Hahn EJ, Paek KY, Park JK, Youn NY, Lee HL. Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction. Asian J Androl. 2009 May;11(3):356-61. doi: 10.1038/aja.2008.32. Epub 2009 Feb 23. PMID: 19234482; PMCID: PMC3735289.

[39] Ginseng improves libido, erectile function and overall satisfaction:

Ham WS, Kim WT, Lee JS, Ju HJ, Kang SJ, Oh JH, Her Y, Chung JY, Park K, Choi YD. Efficacy and safety of red ginseng extract powder in patients with erectile dysfunction: multicenter, randomized, double-blind, placebo-controlled study. Korean journal of urology, 2009, 50(2), 159‐164

[40] Korean red ginseng improved ED symptoms by 60% compared to 30% with an ED drug:

Choi HK, Seong DH, Rha KH. Clinical efficacy of Korean red ginseng for erectile dysfunction. Int J Impot Res. 1995 Sep;7(3):181-6. PMID: 8750052.

[41] Ginsenosides increase dopamine and acetylcholine levels:

Shi J, Xue W, Zhao WJ, Li KX. Pharmacokinetics and dopamine/acetylcholine releasing effects of ginsenoside Re in hippocampus and mPFC of freely moving rats. Acta Pharmacol Sin. 2013 Feb;34(2):214-20. doi: 10.1038/aps.2012.147. Epub 2012 Dec 3. PMID: 23202798; PMCID: PMC4011622.

[42] Ginsenosides may improve nitric oxide production:

Choi YD, Rha KH, Choi HK. In vitro and in vivo experimental effect of Korean red ginseng on erection. J Urol. 1999 Oct;162(4):1508-11. PMID: 10492246.

[43, 44] Ginseng improves energy levels:

Arring NM, Millstine D, Marks LA, Nail LM. Ginseng as a Treatment for Fatigue: A Systematic Review. J Altern Complement Med. 2018 Jul;24(7):624-633. doi: 10.1089/acm.2017.0361. Epub 2018 Apr 6. PMID: 29624410. NYTimes 2012 Jun-18

[45, 46, 47] Ginseng oligopeptides and polysaccharides possess anti-fatigue effects:

Bao L, Cai X, Wang J, Zhang Y, Sun B, Li Y. Anti-Fatigue Effects of Small Molecule Oligopeptides Isolated from Panax ginseng C. A. Meyer in Mice. Nutrients. 2016 Dec 13;8(12):807. doi: 10.3390/nu8120807. PMID: 27983571

Wang J, Li S, Fan Y, Chen Y, Liu D, Cheng H, Gao X, Zhou Y. Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer. J Ethnopharmacol. 2010 Jul 20;130(2):421-3. doi: 10.1016/j.jep.2010.05.027. Epub 2010 May 24. PMID: 20580802.

Wang J, Sun C, Zheng Y, Pan H, Zhou Y, Fan Y. The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome. Arch Pharm Res. 2014 Apr;37(4):530-8. doi: 10.1007/s12272-013-0235-y. Epub 2013 Aug 21. PMID: 23963977.

[48] Ginseng may enhance physical performance, especially in those over 40:

Bucci RL, Selected herbals and human exercise performance. The American Journal of Clinical Nutrition. Volume 72, Issue 2, August 2000, Pages 624S–636S, doi.10.1093/ajcn/72.2.624S

[49, 50, 51] Ginseng significantly improved cognitive performance and reduced mental fatigue:

Reay JL, Kennedy DO, Scholey AB. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol. 2005 Jul;19(4):357-65. doi: 10.1177/0269881105053286. PMID: 15982990.

Reay JL, Scholey AB, Kennedy DO. Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults. Hum Psychopharmacol. 2010 Aug;25(6):462-71. doi: 10.1002/hup.1138. PMID: 20737519.

Reay, Jonathon & Scholey, Andrew & O., Kennedy. (2007). Effects of 8 weeks administration of Korean Panax ginseng extract on the mood and cognitive performance of healthy individuals. Journal of Ginseng Research. Doi: 10.5142/JGR.2007.31.1.034.

[52] Ginseng improved mood and ratings of quality of life:

Reay, Jonathon & Scholey, Andrew & O., Kennedy. (2007). Effects of 8 weeks administration of Korean Panax ginseng extract on the mood and cognitive performance of healthy individuals. Journal of Ginseng Research. Doi: 10.5142/JGR.2007.31.1.034.

[53, 54] Korean red ginseng may increase fat breakdown and prevent the formation of new fat cells:

Shin SS, Yoon M. Korean red ginseng (Panax ginseng) inhibits obesity and improves lipid metabolism in high fat diet-fed castrated mice. J Ethnopharmacol. 2018 Jan 10;210:80-87. doi: 10.1016/j.jep.2017.08.032. Epub 2017 Aug 24. PMID: 28844680.

Park K, Yoon M. Korean Red Ginseng (Panax ginseng) Potentiates the Inhibitory Actions of Testosterone on Obesity and Adipogenesis in High Fat Diet-Fed Castrated Mice. Korean Society For Biomedical Laboratory Sciences. Biomed Sci Letters 2017;23:261-27

[55] Boron beneficially effects testosterone metabolism:

Pizzorno L. Nothing Boring About Boron. Integr Med (Encinitas). 2015 Aug;14(4):35-48. PMID: 26770156; PMCID: PMC4712861.

[56] 10mg boron increased free testosterone by levels by 28% in 7 days:

Naghii MR, Mofid M, Asgari AR, Hedayati M, Daneshpour MS. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. J Trace Elem Med Biol. 2011 Jan;25(1):54-8. doi: 10.1016/j.jtemb.2010.10.001. Epub 2010 Dec 3. PMID: 21129941.

[57] Boron significantly improves the absorption of magnesium and vitamin D:

Pizzorno L. Nothing Boring About Boron. Integr Med (Encinitas). 2015 Aug;14(4):35-48. PMID: 26770156; PMCID: PMC4712861.

58] Boron improved eye-hand coordination tasks, attention and memory:

Penland JG. Dietary boron, brain function, and cognitive performance. Environ Health Perspect. 1994 Nov;102 Suppl 7(Suppl 7):65-72. doi: 10.1289/ehp.94102s765. PMID: 7889884; PMCID: PMC1566632.

[59, 60, 61] Lignans from stinging nettle roots reduce binding activity SHBG:

Schöttner M, Gansser D, Spiteller G. Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG). Planta Med. 1997 Dec;63(6):529-32. doi: 10.1055/s-2006-957756. PMID: 9434605.

Gansser D, Spiteller G. Plant constituents interfering with human sex hormone-binding globulin. Evaluation of a test method and its application to Urtica dioica root extracts. Z Naturforsch C J Biosci. 1995 Jan-Feb;50(1-2):98-104. PMID: 7702715.

Hryb DJ, Khan MS, Romas NA, Rosner W. The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes. Planta Med. 1995 Feb;61(1):31-2. doi: 10.1055/s-2006-957993. PMID: 7700987.

[62, 63] Stinging nettle lignans prevented the binding of DHT by up to 67%:

Hryb DJ, Khan MS, Romas NA, Rosner W. The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes. Planta Med. 1995 Feb;61(1):31-2. doi: 10.1055/s-2006-957993. PMID: 7700987.

Schmidt K. Die Wirkung eines Radix Urticae-Extrakts und einzelner Nebenextrakte auf das SHBG des Blutplasmas bei der benignen Prostatahyperplasie [Effect of radix urticae extract and its several secondary extracts on blood SHBG in benign prostate hyperplasia]. Fortschr Med. 1983 Apr 21;101(15):713-6. German. PMID: 6189775.

[64] Stinging nettle may help slow the conversion of testosterone to estrogen:

Chrubasik JE, Roufogalis BD, Wagner H, Chrubasik S. A comprehensive review on the stinging nettle effect and efficacy profiles. Part II: urticae radix. Phytomedicine. 2007 Aug;14(7-8):568-79. doi: 10.1016/j.phymed.2007.03.014. Epub 2007 May 16. PMID: 17509841.

[65] Daily magnesium supplementation significantly increased testosterone compared to a placebo:

Brilla LR, Haley TF. Effect of magnesium supplementation on strength training in humans. J Am Coll Nutr. 1992 Jun;11(3):326-9. doi: 10.1080/07315724.1992.10718233. PMID: 1619184.

[66] Magnesium enhanced total and free testosterone levels in both active and sedentary men, especially in men who exercised:

Cinar V, Polat Y, Baltaci AK, Mogulkoc R. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion. Biol Trace Elem Res. 2011 Apr;140(1):18-23. doi: 10.1007/s12011-010-8676-3. Epub 2010 Mar 30. PMID: 20352370.

[67] Older men with higher magnesium levels also had higher testosterone levels:

Maggio M, Ceda GP, Lauretani F, Cattabiani C, Avantaggiato E, Morganti S, Ablondi F, Bandinelli S, Dominguez LJ, Barbagallo M, Paolisso G, Semba RD, Ferrucci L. Magnesium and anabolic hormones in older men. Int J Androl. 2011 Dec;34(6 Pt 2):e594-600. doi: 10.1111/j.1365-2605.2011.01193.x. Epub 2011 Jun 15. PMID: 21675994; PMCID: PMC4623306.

[68] Older men are at higher risk of magnesium deficiency:

Costello RB, Moser-Veillon PB. A review of magnesium intake in the elderly. A cause for concern? Magnes Res. 1992 Mar;5(1):61-7. PMID: 1591145.

[69] Low magnesium levels may interfere with the body’s ability to efficiently use energy stores:

Lukaski HC, Nielsen FH. Dietary Magnesium Depletion Affects Metabolic Responses during Submaximal Exercise in Postmenopausal Women. U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202

[70] Magnesium enhances glucose availability to muscles:

Chen HY, Cheng FC, Pan HC, Hsu JC, Wang MF. Magnesium enhances exercise performance via increasing glucose availability in the blood, muscle, and brain during exercise. PLoS One. 2014 Jan 20;9(1):e85486. doi: 10.1371/journal.pone.0085486. PMID: 24465574

[71] Triathlon athletes had faster running, swimming and cycling times after taking magnesium for 4 weeks:

Golf SW, Bender S, Grüttner J. On the significance of magnesium in extreme physical stress. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:197-202. doi: 10.1023/a:1007708918683. PMID: 9794094.

[72] Magnesium significantly increased strength compared to a placebo:

Brilla LR, Haley TF. Effect of magnesium supplementation on strength training in humans. J Am Coll Nutr. 1992 Jun;11(3):326-9. doi: 10.1080/07315724.1992.10718233. PMID: 1619184.

[73] 450mg of magnesium daily was as effective at improving mood as an antidepressant drug:

Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnes Res. 2008 Dec;21(4):218-23. PMID: 19271419.

[74] People taking a daily magnesium supplement slept significantly better than those taking a placebo:

Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012 Dec;17(12):1161-9. PMID: 23853635

[75] Vitamin B6 deficiency is linked to lower testosterone and increased estrogen levels:

Symes EK, Bender DA, Bowden JF, Coulson WF. Increased target tissue uptake of, and sensitivity to, testosterone in the vitamin B6 deficient rat. J Steroid Biochem. 1984 May;20(5):1089-93. doi: 10.1016/0022-4731(84)90348-0. PMID: 6727359.

[76] B vitamins contribute to a normal, energy-yielding metabolism:

European Food Safety Authority, Oct 2010, https://doi.org/10.2903/j.efsa.2010.1757

[77] B vitamins convert amino acids into serotonin and noradrenaline:

Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy–A Review. Nutrients. 2016 Jan 27;8(2):68. doi: 10.3390/nu8020068. PMID: 26828517; PMCID: PMC4772032.

[78] Higher vitamin K intake is linked to lower risk of depressive symptoms:

Bolzetta F, Veronese N, Stubbs B, Noale M, Vaona A, Demurtas J, Celotto S, Cacco C, Cester A, Caruso MG, Reddavide R, Notarnicola M, Maggi S, Koyanagi A, Fornaro M, Firth J, Smith L, Solmi M. The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study. Nutrients. 2019 Apr 5;11(4):787. doi: 10.3390/nu11040787. PMID: 30959758; PMCID: d

[79] HIgher vitamin K intake is associated with improved cognitive performance in those over 70:

Presse N, Belleville S, Gaudreau P, Greenwood CE, Kergoat MJ, Morais JA, Payette H, Shatenstein B, Ferland G. Vitamin K status and cognitive function in healthy older adults. Neurobiol Aging. 2013 Dec;34(12):2777-83. doi: 10.1016/j.neurobiolaging.2013.05.031. Epub 2013 Jul 11. PMID: 23850343.

[80] Vitamin K plays an important role in cognitive health, especially during aging:

Ferland G. Vitamin K and the nervous system: an overview of its actions. Adv Nutr. 2012 Mar 1;3(2):204-12. doi: 10.3945/an.111.001784. PMID: 22516728; PMCID: PMC3648721.

[

81] Bioperine increases bioavailability up to 30%:

https://bioperine.com/index.php/researchhighlight